1. rude slang To lash out emotionally ( often angrily ) . My mom lost her shit when she found out that my sister had taken money from her purse without permission. I never expected Tom to start crying and kicking chairs when he wasn't elected to student council, but he totally lost his shit!
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2. rude slang To lose control of one's mental faculties. Why did I get up from my desk? Oh man, I'm definitely losing my shit.
